英国HS高压纳米均质机、French Pressure Cell高压细胞破碎仪、高压微射流均质机、高压微通道射流均质机
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HS高压均质机在药剂乳剂粒径减小的应用.
栏目:产品资料 发布时间:2021-03-18
HS高压均质机在药剂乳剂粒径减小的应用、HS高压均质机、高压微射流均质机.

一、 药剂乳剂粒径减小的应用

 Producing the smallest, most uniform particle sizes in emulsions and dispersions in the fewest passes, improving product stability.

以最少的均质资料生产粒径最小、最均一的乳剂和分散剂,增加产品的稳定性。

The quality parameters of emulsions, suspensions and dispersions are:

乳剂、分散剂和悬浮剂的质量指标为:

 Smallest droplet size – smallest ratio of droplet surface area to droplet volume.

最小的液滴-液滴表面积和液滴体积的比率最小。

 Narrow particle size distribution – most of the droplets at or below the target size and no "tails" on the distribution graph.

非常窄的粒径分布-大多数的液滴处在或小于靶标尺寸并且没有“拖尾”现象在分布曲线图里。

Our homogenizer's excel at efficiently producing emulsions, suspensions and dispersions with droplets and particles in the size range from a few nanometers to a few micrometers
and very narrow particle size distributions. This is accomplished by three different physical mechanisms: 

我们的高压均质机胜任于高效生产处理带液滴的乳剂、分散剂和悬浮剂,处理后的粒径范围从非常小的纳米到微米级别且粒径分布非常窄。经由三个不同的物理机制完成:

1.Impingement on entry to the nozzle area.

撞击进入喷嘴区。

2.High liquid shear in the nozzle.

高速液体剪切在喷嘴。

3.Sudden pressure drop upon discharge.

卸压时的瞬间压降。

Our Homogenizers - more benefits:

我们均质机-更多益处:

 Production of uniform target nanoparticle sizes in the fewest passes.

以最少的均质次数生产均一尺寸的靶标纳米颗粒。

 Higher stability (longer shelf life).

更高的稳定性(更长的保质期)。

 Sterilisation by filtration (for medical suspensions).

医用悬浮剂的过滤灭菌。

 Higher efficacy (absorption), controlled release, odour and flavour masking.

更高的吸收效率、控制缓释、气味和风味的掩盖。

The benefits above, and others, often lead to lower production costs. Our on-going maintenance costs are also some of lowest in the industry.

以上的益处,和其它的优势所带来更低的生产成本。我们后继的维护费用也是工业里最低的。

Our Homogenizers - more features:

我们均质机的更多特点

The following unique features enable the user to create emulsions and dispersions with smallest particles sizes and narrowest particle size distributions in the smallest number of
passes: 

以下的独特特征可使用户以最少的均质次数创造最小粒径和最窄粒径分布的乳剂和悬浮剂:

 High, Very High and Ultra High Pressure Homogenizers, to maximise the intensity of the process.

高压、非常高压和超高压均质机,以最大限度的提高处理过程的强度。

 Exceptionally wide range of pressure, for maximum versatility.

非常广泛的压力范围,可获得最大的通用性。

 Precise control of the pressure throughout the range, and constant pressure once set, for narrowest particle size distribution, reproducibility and scalability.

精确控制量程内的压力,设定后即可保持恒定压力,可获得最窄粒径分布,具有优良的重现性和可扩展性。

 Sophisticated temperature control systems, including pre- and post-cooling or heating, to preserve product integrity.

精密的温度控制系统,包括预冷和出料冷却或加热,以保持产品的完整性。

The table below illustrates.

下表说明产品和建议的压力范围-以MPa和psi为单位

Products and Pressure Ranges - in MPa and psi

Liposomes脂质体

20 to 150 MPa  --> 3000 to 22,000 psi

Encapsulation包封

20 to 150 MPa  --> 3000 to 22,000 psi

Microemulsions微乳

20 to 200 MPa  --> 3000 to 30,000 psi

Deagglomeration松团作用

20 to 350 MPa  --> 3000 to 50,000 psi

Nanosuspensions纳米悬乳剂

20 to 400 MPa  --> 3000 to 60,000 psi

Polysaccharides多糖

Nano Cellulose纳米纤维素

(1)Preheating to 80°C (lipid melt temperature) is possible.

可预热到80°C (脂质融化温度)

 

二、 药剂乳剂的应用例子


三、 各类药剂建议使用的压力 

脂质体:20 -150MPa  3,000-22,000psi 

包封:20 -150MPa  3,000-22,000psi 

纳米乳剂:20 -200MPa  3,000-30,000psi 

脂质纳米粒:50 -200MPa  7,000—30,000psi 

解聚,分散:20 -350MPa  3,000—50,000psi 

纳米混悬剂,如碳纳米管:20 -400MPa  3,000-60,000psi 

四、建议购买的设备型号 

nG12800 (SPCH-20 带 10ml腔体) : 工作压力 20-400MPa;处理量:3ml-1500ml 

SPCH-EP-IC-20-30 :工作压力20-210MPa;处理量:3ml-5L 

nG7575-06-09T-20 :工作压力20-210MPa;处理量:500ml-85L/H

nG7575-10-09T-32:工作压力20-350MPa;处理量:500ml-55L/H


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英国HS高压纳米均质机、French Pressure Cell高压细胞破碎仪、高压微射流均质机、高压微通道射流均质机